Gastroretentive Drug Delivery System of Ranitidine Hydrochloride Based on Osmotic Technology: Development and Evaluation
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چکیده
منابع مشابه
Formulation Development and Evaluation of Hydrogel Based Gastroretentive Drug Delivery System of Antihypertensive Drug
Site specific drug delivery has become the important aspect of research. In present study focused has been made to formulate gastroretentive drug delivery (GRDDS) of drugs having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site. Hydrogel based gastroretentive formulation of ramipril were prepared by gas blowing techni...
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The present investigation describes the design and evaluation of monolithic gastro retentive dosage forms of diltiazem. Hydrophilic cellulose derivatives, Sodium alginate, Sodium carboxy methyl cellulose, Polyox, Methocel K100M in combination with Methocel E6LV are used as the rate controlling polymers. Sodium bicarbonate was incorporated as gas generating agent. Tablets were prepared by employ...
متن کاملAn Overview on Gastroretentive Drug Delivery System
Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...
متن کاملDevelopment and optimization of metoprolol succinate gastroretentive drug delivery system.
Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...
متن کاملDevelopment and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology.
Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was ...
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ژورنال
عنوان ژورنال: Current Drug Delivery
سال: 2008
ISSN: 1567-2018
DOI: 10.2174/156720108785914943